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Evidence worth finding again
Detailed walkthroughs of selected new studies, alongside a concise, topic-led collection of the papers, guidelines and reviews that have shaped liver critical care.
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Showing Transplantation and peri-transplant critical care
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13 papers
Evidence Deep Dives
ACLF
Therapeutic plasma exchange in ACLF: what the randomised trial found
Swaroop and colleagues randomised 194 adults with ACLF to therapeutic plasma exchange plus standard medical therapy or standard therapy alone. This Evidence Deep Dive examines the study population, treatment protocol, 28- and 90-day outcomes, and the questions raised by the difference between early and later survival.
Hepatology30 Mar 2026
Read Deep Dive →Key papers
Transplantation and peri-transplant critical care
- Therapeutic plasma exchange improves short-term survival in patients with acute-on-chronic liver failure: a randomized controlled trial ↗
Swaroop S, Biswas S, Aggarwal A, et al.
Hepatology30 Mar 2026Original research
- MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era ↗
Kim WR, et al.
Gastroenterology1 Dec 2021Landmark study
- Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis ↗
Lee BP, et al.
Gastroenterology1 Aug 2018Landmark study
- Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation ↗
Sundaram V, et al.
Gastroenterology1 Apr 2019Original research
- Liver transplantation for critically ill cirrhotic patients: Stratifying utility based on pretransplant factors ↗
Artzner T, et al.
American Journal of Transplantation1 Sept 2020Original research
- Acute Liver Failure Guidelines ↗
Shingina A, et al.
American Journal of Gastroenterology1 Jul 2023Guideline or consensus
- EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure ↗
European Association for the Study of the Liver
Journal of Hepatology1 May 2017Guideline or consensus
- Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3 ↗
Artru F, et al.
Journal of Hepatology1 Oct 2017Landmark study
- Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: Results of the ELITA/EF-CLIF collaborative study (ECLIS) ↗
Belli LS, et al.
Journal of Hepatology1 Sept 2021Landmark study
- Early liver transplantation for severe alcoholic hepatitis ↗
Mathurin P, et al.
New England Journal of Medicine10 Nov 2011Landmark study
- A model to predict survival in patients with end-stage liver disease ↗
Kamath PS, et al.
Hepatology1 Feb 2001Landmark study
- Elective liver transplant list mortality: development of a United Kingdom end-stage liver disease score ↗
Barber K, et al.
Transplantation27 Aug 2011Landmark study