Liver Critical Care Hub
LCCH Physiology.
Visual and mechanistic physiology built around the problems that matter in liver critical care — from circulation and kidney failure to ammonia, portal pressure, haemostasis and metabolic failure.
Explore scenarios, compare reference and failure states, and test your reasoning. Open deeper explanations whenever you need them.
Physiology library
Built around liver critical care.
The organising questions are the ones that recur on liver ICU. The visual model is the entry point; deeper layers separate established physiology from areas that remain nuanced or evolving.
7 modules to explore
Cirrhotic haemodynamics & HRS-AKI
Why does cirrhosis cause renal failure?
- Volume
- Interpretation
Ammonia & hepatic encephalopathy
How does ammonia become a brain problem?
- Nitrogen
- Brain
Portal pressure, varices & TIPS
What actually determines portal pressure — and what does TIPS change?
- Circuit
- Measurement
Bilirubin, bile formation & cholestasis
Where does bilirubin go wrong in critical illness?
- Polarity
- Pattern
Lactate & hepatic metabolic failure
Why does lactate mean something different when the liver is failing?
- Flux
- Energy
Rebalanced haemostasis
How can the INR be prolonged while thrombosis remains possible?
- Assays
- Bleeding
Cirrhotic cardiomyopathy
How can a high-output circulation hide cardiac dysfunction?
- Loading
- Reserve
How to read a module
Visual entry point. Mechanistic depth.
Start with an overview or go straight to a clinical problem. Each module brings together a visual mechanism, interactive scenarios, detailed explanations and source-linked interpretation.
Build the organising model, from normal physiology to failure.
Compare scenarios and explore how a disturbance affects the whole system.
Open the cellular and organ-level explanations that sharpen clinical interpretation.
Understand the intended effect, the trade-offs and what the model leaves out.
Apply the mechanism, read the feedback and follow the supporting evidence.
Connected physiology
One syndrome rarely belongs to one organ.
Educational physiology resource. Visual models deliberately simplify complex, heterogeneous syndromes; modules distinguish established physiology from areas that remain nuanced or evolving and do not replace current clinical guidance.