01Reviewed July 2026
Acute-on-chronic liver failure
Definitions, organ failure, early ICU management and transplant thinking.
Guidelines and position statementsReviews and useful resources
Open topic →Knowledge Portal
Knowledge Portal
A brief orientation to each core liver critical care topic, followed by relevant guidelines and position statements, then selected reviews and other useful resources.
Core topics
Browse by topic
Each topic page brings together external guidance and carefully selected supporting resources. The Hub summarises the scope of the topic but does not provide a course or curriculum.
02Reviewed July 2026
Acute liver failure
Recognition, aetiology, cerebral risk, organ support and emergency transplantation.
Guidelines and position statementsReviews and useful resources
Open topic →03Reviewed July 2026
AKI and hepatorenal syndrome
Phenotyping kidney injury, HRS-AKI, vasoconstrictors, RRT and transplantation.
Guidelines and position statementsReviews and useful resources
Open topic →04Reviewed July 2026
Encephalopathy and cerebral complications
Diagnosis, precipitants, ammonia, airway protection and ALF-specific cerebral risk.
Guidelines and position statementsReviews and useful resources
Open topic →05Reviewed July 2026
Infection and sepsis in cirrhosis
Cirrhosis-associated immune dysfunction, resistant organisms and early sepsis care.
Guidelines and position statementsReviews and useful resources
Open topic →06Reviewed July 2026
Portal-hypertensive bleeding
Resuscitation, vasoactive therapy, endoscopy, pre-emptive TIPS and rescue options.
Guidelines and position statementsReviews and useful resources
Open topic →07Reviewed July 2026
Haemostasis in liver disease
Rebalanced haemostasis, test interpretation, procedures, bleeding and thrombosis.
Guidelines and position statementsReviews and useful resources
Open topic →08Reviewed July 2026
Transplant referral and peri-transplant care
Selection, timing, bridging, perioperative care and early graft complications.
Guidelines and position statementsReviews and useful resources
Open topic →09Reviewed July 2026
Decompensated cirrhosis
Recognising acute decompensation, treating precipitants and preventing further organ failure.
Guidelines and position statementsReviews and useful resources
Open topic →10Reviewed July 2026
Alcohol-associated hepatitis
Diagnosis, severity assessment, corticosteroids, infection, alcohol use disorder and transplantation.
Guidelines and position statementsReviews and useful resources
Open topic →11Reviewed July 2026
Extracorporeal liver support and RRT
RRT, ammonia clearance, albumin dialysis, plasma exchange and bridge-to-transplant decisions.
Guidelines and position statementsReviews and useful resources
Open topic →12Reviewed July 2026
Prognostication and ICU decisions
Dynamic risk, transplant potential, time-limited ICU trials, communication and palliative care.
Guidelines and position statementsReviews and useful resources
Open topic →13Reviewed July 2026
Nutrition, frailty and rehabilitation
Screening, protein and energy delivery, sarcopenia, frailty, prehabilitation and recovery.
Guidelines and position statementsReviews and useful resources
Open topic →