Knowledge Portal
A brief orientation to each core liver critical care topic, followed by relevant guidelines and position statements, then selected reviews and other useful resources.
Start here
A short reading route for clinicians who want a broad grounding in liver critical care before moving into specific conditions and complications.
General ICU
Van Eldere A, Pirani T. Anaesthesia. 2023;78(7):884–901.
A broad introduction to approaching liver dysfunction in general critical care: recognising the clinical syndrome, interpreting abnormal liver biochemistry, initial management and knowing when specialist liver input is required.
Read article ↗Go deeper
Kosuta I, Premkumar M, Reddy KR. Aliment Pharmacol Ther. 2024;59(12):1489–1509.
A contemporary, comprehensive review of critical care for patients with cirrhosis, including organ support, infection, nutrition, liver support, transplantation and end-of-life care.
Read article ↗Fernández J, Bassegoda O, Toapanta D, Bernal W. JHEP Rep. 2024;6(9):101131.
A practical modern review of acute liver failure, including recognition, aetiology, organ support, neurological complications, sepsis and transplantation.
Read article ↗Karvellas CJ, Gustot T, Fernandez J. Liver Int. 2025;45(3):e15659.
An ICU-focused review of ACLF, covering admission, treatment of precipitants, organ support, prognosis, liver support, transplantation and when recovery is unlikely.
Read article ↗Starter literature last reviewed 26 August 2026.
Core topics
The Knowledge Portal and Research library use the same topic structure, so each page connects directly to its relevant Key Papers and Evidence Deep Dives.
Definitions, organ failure, early ICU management and transplant thinking.
Recognition, aetiology, cerebral risk, organ support and emergency transplantation.
Phenotyping kidney injury, HRS-AKI, vasoconstrictors, RRT and transplantation.
Diagnosis, precipitants, ammonia, airway protection and ALF-specific cerebral risk.
Cirrhosis-associated immune dysfunction, resistant organisms and early sepsis care.
Resuscitation, vasoactive therapy, endoscopy, pre-emptive TIPS and rescue options.
Rebalanced haemostasis, test interpretation, procedures, bleeding and thrombosis.
Selection, timing, bridging, perioperative care and early graft complications.
Recognising acute decompensation, treating precipitants and preventing further organ failure.
Diagnosis, severity assessment, corticosteroids, infection, alcohol use disorder and transplantation.
RRT, ammonia clearance, albumin dialysis, plasma exchange and bridge-to-transplant decisions.
Dynamic risk, transplant potential, time-limited ICU trials, communication and palliative care.
Screening, protein and energy delivery, sarcopenia, frailty, prehabilitation and recovery.
Definition, grading, prevention, organ support and rescue options after liver resection.
Perioperative risk assessment, optimisation and postoperative planning for patients with cirrhosis undergoing non-hepatic surgery.