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Evidence worth finding again

Detailed walkthroughs of selected new studies, alongside a concise, topic-led collection of the papers, guidelines and reviews that have shaped liver critical care.

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Showing Organ support and extracorporeal therapies

All topics61Acute-on-chronic liver failure25Acute liver failure8Decompensated cirrhosis27Alcohol-associated hepatitis4Post-hepatectomy liver failure3Cirrhosis and non-hepatic surgery4Encephalopathy and cerebral complications4AKI and hepatorenal syndrome8Infection and sepsis4Portal hypertension and variceal bleeding7Haemostasis and thrombosis2Transplantation and peri-transplant care14Organ support and extracorporeal therapies15Prognostication and ICU decision-making25

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15 papers

Evidence Deep Dives

Acute-on-chronic liver failure

Plasma exchange in ACLF: a real 28-day signal that does not survive to 90 days

A 194-patient randomised trial found that a strategy of five planned sessions of standard-volume therapeutic plasma exchange reduced 28-day mortality by 19.6 percentage points. The difference was no longer evident at 90 days, 42% did not complete all five sessions, and the cohort did not include patients with active infection, haemodynamic instability or respiratory organ failure.

Hepatology30 Mar 2026
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Organ support and extracorporeal therapies