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Evidence worth finding again

Detailed walkthroughs of selected new studies, alongside a concise, topic-led collection of the papers, guidelines and reviews that have shaped liver critical care.

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All topics54ACLF22Acute liver failure8Cirrhosis in critical care25Alcohol-associated hepatitis4Encephalopathy and cerebral complications4Transplantation and peri-transplant critical care13Organ support9Renal dysfunction8Infection and sepsis4Haemostasis and thrombosis2Portal hypertension and variceal bleeding6Circulatory failure7Post-hepatectomy liver failure3Prognostication, phenotyping and research methods20

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ACLF

Therapeutic plasma exchange in ACLF: what the randomised trial found

Swaroop and colleagues randomised 194 adults with ACLF to therapeutic plasma exchange plus standard medical therapy or standard therapy alone. This Evidence Deep Dive examines the study population, treatment protocol, 28- and 90-day outcomes, and the questions raised by the difference between early and later survival.

Hepatology30 Mar 2026
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